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| Diagrammatic representation of virus This image can be used only by giving a link to this article. |
Virus is a nucleic acid, either DNA or RNA which is
infectious in nature. Virus can infect all kind of organisms including plants,
animals and bacteria. This nucleic strand of the DNA is called genome. Outside
genome there is covering of proteinaceous coat called capsid. Outside the capsid
there presents a fatty envelope. Capsid and genome together is known as
nucleocapsid and all the three capsid, genome and envelope together is known as
virion. Virus is an obligate parasite i.e. active only inside the host cells.
Virus is also known as the connecting link between living and non-living
organisms.
Stages of
replication of virus: Virus infects and replicates inside the
host cell and these whole process occurs in various stages. Virus replication
can be divided into the following stage-
a) Adsorption- This is the first step of DNA replication;
virus comes in the contact of host cell and occupies the predefined receptors
for attachment of the same.
b) Penetration- After adsorption, Virus penetrates the host
cell hence reaching inside the cell.
c) Uncoating- Uncoating is the middle stage of the virus
replication. Capsid of the virus is dissolved and genome id exposed to the host
cell.
d) Biosynthesis- After uncoating, next step is the
biosynthesis. In this stage biosynthesis of nucleotides, proteins etc. occur. This
is also called as the stage of dividing of virus.
e) Maturation- In this stage, virus gets matured inside the
host cell and ready to infect other cells.
f) Release- This is the last stage of virus replication. All
the new biosynthesized viruses are released from the host cell to infect other
cells.
Classification of antivral drugs:
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| Structure of antiviral drugs This image can be used only by giving a link to this article. |
Classification of antiviral drugs is done on the basis of
specific virus against these classes are active. Antiviral drugs are classified
into following classes-
a) Anti-herpes virus- Acyclovir, Gancyclovir, Idoxuridine
& Foscarnent.
b) Anti-influenza virus- Amantadine & Rimantadine
c) Broad spectrum antivral drugs- Vidabarine &
Ribavarine
d) Anti-HIV virus- Stavudine, Zidovudine, Carbovir &
Didanosine
e) Anti-small pox virus- Methisazone & Anildone
Mechanism of action of antiviral drugs:
Here I am discussing the individual mechanism of action of
each class of antiviral drugs. All classes have their distinguished mechanisms
to inhibit the viral growth.
a) Mechanism of action of anti-herpes virus drugs-
Subfamily of herpes virus includes
HSV-1, HSV-2 and varicolla zoster, cytomegalovirus and Epstein barr virus. Mechanism
of anti-herpes virus is as follows-
Thymidyl kinase of the host cell converts acylvovir into
acyclovir guanosine monophosphate(GMP), which is further metabolized to
acyclovirGTP by the host cells. This acyclovirGTP is responsible for inhibiting
the DNA polymerase and hence inhibits the DNA replication of Viral DNA.
Major adverse effects of acyclovir-
i) GI upset and headache after oral administration
ii) Renal dysfunction after i.v. dose
b) Mechanism of action of anti-influenza virus drugs-
There are two major respiratory
tract viruses- Influenza virus A,B & C and respiratory syncital virus.
In normal cases, virion is engulfed by host cells and within
the host cell the nucleocapsid is lodged into endosomes. Acid metabolites of
the host cell help nucleocapsid to fuse with the endosome. This cause removal
of the capsid and genome is released into host cell cytosol.
Amantadine being weakly basic in nature neutralizes the acid
metabolites hence results in no uncoating and no replication of the virus. Although
amantadine is safe nature but can produce CNS symptoms.
c) Mechanism of broad spectrum anti-viral drugs-
Broad spectrum anti-viral drugs are
synthetic nucleosides. Generally, they combine with phosphate compounds and
hence inhibiting DNA & RNA synthesis.
Adverse effects of broad spectrum anti-viral drugs-
i) Anemia
ii) Bronchospasm
d) Mechanism of action of anti-HIV drugs-
AIDS was discovered in 1981
caused by HIV virus (retrovirus). HIV infects CD4 & T4 cells required for
the cell mediated immunity which results in the death of CD4 & T4 cells. Cell mediated immunity collapse and ultimately results in death.
All drugs which act against HIV are Deoxynucleosides.
First of all anti-HIV drug is converted to TTP derivative
which after binding with the reverse transcriptase incorporated into the DNA
chain of the virus. This prevents the replication and elongation of the chain.
Adverse effects of anti-HIV drugs-
i) Anemia
ii) Granulocytopenia
iii) Thrombocytopenia
e) Mechanism of action of anti-smallpox virus drugs-
Anti-smallpox virus drugs act by
inhibiting the protein synthesis in the biosynthesis stage of the virus
replication. This ultimately results in the inhibition of the virus
replication.
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