Objective questions for the GPAT: Pharmacology selected topics

Here is another objective questions test series for the preparation of GPAT. Questions included in this series are made by a team of experts who have qualified GPAT with very good ranks. All the questions given here have very high probability of being asked in the GPAT. Topics included in this series are:
1. Antiepiletic drugs.
2. Anticancer drugs.
3. Sedative-Hypnotics.
4. Migraine & drugs used for the treatment.
5. General anesthetics

 Answers to this is provided below in the first comment.

1. Which of the following is the first line drug for the treatment of status epilepticus?
a) Phenobarbitone.
b) Phenytoin
c) Valproic acid
d) Carbazepine

2. Phenytoin the drug used for the treatment of epilepsy has main side effect:
a) Gum hypertrophy
b) Hepatotoxicity
c) Arrhythmia
d) Nephrotoxic

3. Which of the following is a prodrug for the treatment of epilepsy?
a) Phenytoin
b) Phenobarbitone
c) Primidone
d) Ethosuximide

4. Which of the following is the first line drug for the treatment of Generalised tonic clonic and partial seizure ?
a) Phenobarbitone.
b) Phenytoin
c) Valproic acid
d) Carbazepine

5. Which of the following antiepileptic drugs are used for the treatment of absence seizures?
a) Primidone
b) Ethosiximide
c) Phenobarbitone
d) Carbamazepine

6. Apart from its main use as entiepileptic agent, this drug is also used in the prophylaxis of migraine.
a) Phenobarbitone.
b) Phenytoin
c) Valproic acid
d) Carbazepine

7. Which of the following can be used as alternate to Li in mood and bipolar disorder?
a) Carbazepine
b) Valproic acid
c) Both a & b
d) None of the above

8. The antiepileptic drug which is contraindicated in the pregnancy is;
a) Phenobarbitone.
b) Phenytoin
c) Valproic acid
d) Carbamazepine

9. Which of the following antiepileptic drugs are used for the treatment of complex partial seizures?
a) Primidone
b) Ethosiximide
c) Phenobarbitone
d) Carbamazepine


10. The main mechanism of action of one of the following drug is that act through inhibiting Ca ion channels:
a) Primidone
b) Ethosiximide
c) Phenobarbitone
d) Carbamazepine

11. Which of the following drug is serotonin agonist & used for the treatment of migraine?
a) Sumatriptan
b) Methysergide
c) Risperidone
d) Clozapine

12. Which of the following is not a class of drug used for the treatment of migraine?
a) NSAIDs
b) Beta blockers
c) Alpha antagonists
d) Serotonin agonists

13. Alyklating agents are used for the treatment of cancer. Most of them exerts their mechanism of action by acting as prodrug. Which of the following alkylating agent is not a prodrug used for cancer treatment.
a) Cyclophosphamide
b) Thiotepa
c) Carmustine
d) Busulfan

14. Alklylating agents shows their mechnism of acion through alylation of DNA, alkylation is done at which phase of the cell cycle?
a) G1 phase
b) G2 phase
c) G0 phase
d) G1 & S phase

15. Which of the following is a purine antagonist used for the treatment of cancer?
a) Methotrexate
b) Cytrabine
c) 5-flurouracil
d) Cladibrine

16. Which of the following is a pyrmidine antagonist used for the treatment of cancer?
a) Methotrexate
b) Cytrabine
c) Thioguanine
d) Cladibrine

17. Plant alkaloids used for the treatment of cancer which act through topoisomerase-II inhibitor is:
a) Phyllotoxins
b) Campothecins
c) Both a & b
d) None of the above

18. Plant alkaloids used for the treatment of cancer which act as tubule synthesis inhibitor:
a) Phyllotoxins
b) Campothecins
c) Taxanes
d) Vincristines

19.  Plant alkaloids used for the treatment of cancer which act as spindle poision?
a) Phyllotoxins
b) Campothecins
c) Taxanes
d) Vincristines

20. One of the following is antiestrogen drug mainly used for the treatment of breast cancer.
a) Imitanib
b) Tamoxifen
c) Cetuximab
d) Cladibrine

21. One of the following anticancer agent acts as EGRF antagonist.
a) Imitanib
b) Tamoxifen
c) Cetuximab
d) Cladibrine

22. Target enzyme for the treatment of cancer for Imitanib is
a) Thymidyl snthetase
b) Tyrosine kinase
c) DNA polymerase
d) RNA polymerase

23. First line drug for the treatment of leukemia is:
a) Imitanib
b) Tamoxifen
c) Cetuximab
d) Cladibrine

24. Factor which increases the minimum alveolar concentration of a general anesthetic is:

a) Hypernatrimia

b) Hypotention

c) Hypoxia

d) Hypothermia

25. Which of the general anesthetic exerts its mechanism of action through stabilizing GABA-receptor complex?

a) Isoflurane

b) Halothane

c) Ketamine

d) Nitrous oxide

26. Which of the general anesthetic exerts its mechanism of action through antagonizing the Na+ in N-methyl-D-aspartate (NMDA) receptor complex?

a) Isoflurane

b) Halothane

c) Barbiturates

d) Nitrous oxide

27. One of the following genral anesthetic is banned in developed countries due to its toxicity.

a) Ether

b) Halothane

c) Isoflurane

d) Nitrous oxide

28. Genral anesthetic which also produce bronchodilation and can be safer for athmatics is:

a) Ether

b) Halothane

c) Isoflurane

d) Nitrous oxide

29. General anesthetic considered most safe for the patient of myocardial ischemia is

a) Ether

b) Halothane

c) Isoflurane

d) Nitrous oxide

30. General anesthetic preferred for the neurosurgery is:

a) Ether

b) Halothane

c) Isoflurane

d) Nitrous oxide

31. Thiopentone sodium ultra short acting general anesthetic is contraindicated with one of the following drug in same syringe due to chemical instability.

a) Succinyl choline

b) Ketamine

c) Diazepam

d) propofol

32. Genral anesthetic which is known for producing dissociative anesthesia:

a) Succinyl choline

b) Ketamine

c) Diazepam

d) propofol

33. General anesthetic containdicated for the heart patients is:

a) Succinyl choline

b) Ketamine

c) Diazepam

d) propofol

34. Which of the following drug can produce insomnia as its side effect?

a) Ritanserin

b) propanol

c) Diphenylhydramine

d) Cetrizine

35. Methoxamine drug which produce alertness in the person mainly acts as a:

a) Alpha receptor agonist

b) Beta receptor antagonist

c) Adenosine receptor agonist

d) All of the above

36. Which of the following sedative-hypnotic is melatonin receptor agonist?

a) Ritanserin

b) Methoxamine

c) Ramelton

d) None of the above

37. Long acting barbiturate among the following is:

a) Phenobarbitone

b) Pentobarbitone

c) Thiopentone

d) Butobarbitone

38. Ultra short acting barbiturate among the following is:

a) Phenobarbitone

b) Pentobarbitone

c) Thiopentone

d) Butobarbitone

39. Which of the following benzodiazepine drug act as hypnotic, antianxiety & anticonvulsant?

a) Diazepam

b) Lorazepam

c) Flurazepam

d) Alprazolam

40. barbiturates exerts their mechanism of action by acting as:

a) GABA facilitator

b) GABA mimetic

c) Both of the above

d) None of the above

41. Barbiturate is well known drug which act as cytochrome inducer hence altering the metabolism of many drugs. Plasma concentration of following drug is decreased by barbiturates.

a) Warfarin

b) Contraceptives

c) Tolbutamide

d) All of the above

42. Which of the following drugs show synergistic effect with barbiturates?

a) opoids

b) Contraceptives

c) Adrenegic blockers

d) Antidiuretics

43. Whch of the following factors responsible for the decreased lipophilicity of the barbiturates hence increasing the duration of action?

a) Aromatic substitution carbon 5

b) Aliphatic substitution at carbon 5

c) Substitution at N1.

d) Replacement of S at carbon 2.

44. Whch of the following factors responsible for the increased lipophilicity of the barbiturates hence decreased the duration of action?

a) Aliphatic substitution at carbon 5

b) Substitution at N1.

c) Replacement of S at carbon 2.

d) All of the above

45. Which of the cytochrome enzyme is responsible for the oxidation of barbiturates at carbon no. 5?

a) CYP2C19

b) CYP2C29

c) CYP2C39

d) CYP2C49

46. Which of the following drug is benzodiazepine competitive antagonist?

a) Flumazenil.

b) Bicculine

c) β-Carboline

d) Zolepon

47. Which of the following drug is benzodiazepine non-competitive antagonist?

a) Flumazenil.

b) Bicculine

c) β-Carboline

d) Zolepon

48. Which of the following drug is benzodiazepine inverse agonist?

a) Flumazenil.

b) Bicculine

c) β-Carboline

d) Zolepon

49. Shortest acting non benzodiazepine hypnotic is:

a) Zoplicone

b) Zolpidem

c) Zolepon

d) Bicculine

50. Which of the following is used as a precursor for the synthesis of barbituric acid?

a) Malonic acid

b) Accetoacetic ester

c) Urea

d) Both a & c

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