Sunday, 7 December 2014

Objective questions of Pharmacology for GPAT: Autonomic nervous system

Here is the next series of objective questions for the GPAT. In this, whole pharmacology and chemistry of the autonomic nervous system will be covered. Hope it will help you all in your preparation. For reference you can read our complete article on pharmacology of autonomous nervous system.

1. Who coined the term enteric nervous system?
a) James langley
b) Paul Ehlrich
c) Watson
d) Alexander Fleming

2. Receptor responsible for the reuptake of the adrenaline at synapse is:
a) α2
b) β1
c) α1
d) β2

3. Receptor responsible for the bronchodilation is:
a) α2
b) β1
c) α1
d) β2

4. Receptor responsible for vasoconstriction and results in increased blood  pressure is:
a) α2
b) β1
c) α1
d) β2

5. Receptor of the sympathetic nervous system present in heart and responsible for the contraction is:
a) α2
b) β1
c) α1
d) β2

6. The 10th cranial nerve originates from:
a) midbrain
b)  dorsal nucleus of vagus
c) Inferior salivary nucleus
d) superior salivary nucleus

7. The 3rd cranial nerve originates from:
a) midbrain
b)  dorsal nucleus of vagus
c) Inferior salivary nucleus
d) superior salivary nucleus

8. The 7th cranial nerve originates from:
a) midbrain
b)  dorsal nucleus of vagus
c) Inferior salivary nucleus
d) superior salivary nucleus

9. The 9th cranial nerve originates from:
a) midbrain
b)  dorsal nucleus of vagus
c) Inferior salivary nucleus
d) superior salivary nucleus

10. Neurotransmitter present at synapse of symathetic nervous system is:
a) Accetylcholine
b) Adrenaline
c) Noradrenaline
d) Dopamine

11. Receptor present at neuromuscular junstion is:
a) Nicotinic (Nn)
b) Nicotinic (Nm)
c) α1
d) β2

12. Indirect acting cholinergic drug among the following is:
a) Pilocarpine
b) Lobeline
c) Bethachol
d) Endrophonium

13. Which of the following is a selective muscranic cholinergic drug?
a) Accetylcholine
b) Pilocarpine
c) Lobeline
d) Carbachol


14. Which of the muscranic receptor is present in the brain?
a) M1
b) M2
c) M3
d) M4

15. Which of the muscranic receptor is present in the heart?
a) M1
b) M2
c) M3
d) M4

16. The main action of the following drug is it acts as ganglion blocker and used as spasmolytic.
a) Triethylcholine
b) Dicyclomine
c) Hemicholinium
d) Succinyl choline

17. Following neuromuscular blocker acts by depolarising the neuromuscular junction resulting in the paralysis of the muscle:
a) Triethylcholine
b) Dicyclomine
c) Hemicholinium
d) Succinyl choline

18. Which of the following pharmacological action is due to the stimulation of α1 receptor?
a) Dilator pupillae (Dilation)
b) Vascular smooth muscles ( Constriction)
c) Platelet (Aggregation)
d) Heart (Stimulate)

19. Platelet aggregation is a result of the stimulation of which recptor?
a) α2
b) β1
c) α1
d) β2

20. Glycogenolysis in human being is associated with the stimulation of following receptor:
a) α2
b) β1
c) α1
d) β2

21. Lipolysis occurs in human being due to the stimulation of which receptor?
a) α2
b) β1
c) α1
d) β3

22. To have increased sympathomimetic activity, N atom should be optimally separated with phenyl ring by how many carbon atoms?
a) 1
b) 2
c) 3
d) 4

23. To have increased selective β2 activity, the basic ring (β-phenyl ethyl amine) of sympathomimetics should be substituted at position 3 & 5 with:
a) Methoxy
b) Amino
c) Hydroxy
d) Methyl

24. Drug used for the treatment of Pheochromocytopenia is:
a) Phenoxabenzamine
b) Prazocin
c) Labetolol
d) Esmolol

25. Which of the following drug is selective α1 blocker?
a) Phenoxabenzamine
b) Prazocin
c) Labetolol
d) Esmolol

26. Non selective α & β blocker is:
a) Phenoxabenzamine
b) Prazocin
c) Labetolol
d) Esmolol

27. Selective β1 blocker used in the treatment of Supraventricular tachycardia is
a) Phenoxabenzamine
b) Prazocin
c) Labetolol
d) Esmolol

28. Selective β1 blocker used in the treatment of angina and arrythmia is:
a) Phenoxabenzamine
b) Prazocin
c) Labetolol
d) Acebutalol

29. The portion of neuromuscular junction where terminal knob of neuron enters the muscles is:
a) motor nerve
b) motor end plate
c) Subneurol cleft
d) motor nerve twig

30. Who is the father of ANS physiology?
a) James langley
b) Paul Ehlrich
c) Watson
d) Alexander Fleming

31. The concept of one neuron one transmitter is given by:
a) James langley
b) Paul Ehlrich
c) Henry Dale
d) Alexander Fleming

32. Glycogenolysis in rat is associated with the stimulation of following receptor:
a) α2
b) β1
c) α1
d) β2

33. Precursor for the biosynthesis of adrenaline is:
a) Tyrosine
b) Histidine
c) Tryptophan
d) None of the above

34. Atenolol is selective blocker of:
a) α2
b) β1
c) α1
d) β2

35. Reuptake of noradrenaline at synapse is an example of which phenomenon?
a) Homotropic inhibition
b) Heterotropic inhibition
c) Denervation supersensitivity
d) None of the above

36. Fight or flight mechanism is explained by:
a) Cannon
b) Paul Ehlrich
c) Henry Dale
d) Alexander Fleming

37. Which of the following is the best suitable justification for the Denervation supersensitivity?
a) Increase in no. Of receptor. 
b) No reuptake as there will be no presynaptic membrane. 
c) Enhanced postreceptor binding effect.
d) All of the above

38. Non selective cholinergic drug among the following is:
a) Carbachol
b) Nicotine
c) Bethanechol
d) Methacholine

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3 comments:

  1. 1a, 2a,3d,4c,5b,6b,7a,8d,9c,10a,11b, 12d,13b,14a,15b,16b,17d,18a,19a,20d,21d,22b,23c,24a,25b,26c,27d,28d,29b,30a,31c,32c,33a,34b,35a,36a,37d,38a

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