Here is another important topic for the GPAT preparation. Every year you well get fair amount of questions in the GPAT exam from this topic. We have tried to explain this topic simply and interactively. Don't forget to mention your any doubt in the comment below. We will be happy to clarify it by the experts of our team.
Pharmacology of individual Class
a) Alkylating agents:
Mechanism of action:
b) Antimetabolites:
1. Methotrexate: Folic acid antagonists.
1. Vinca alkaoids: Vincristine & Vinblastin (Tubule synthesis inhibitor).
2. Epidophyllotoxins: Inhibits Topoisomerase-II-------> DNA breakage.
3. Campothecin: Inhibits Topoisomerase-II.
4. Taxanes: Acts as spindle poison (mitotic).
d) Antiestrogen: Tamoxifen (Breast cancer).
e) Miscellaneous drugs:
Classification of anticancer agents
![]() |
Classification of anticancer agents |
a) Alkylating agents:
![]() |
Alkylating agents |
Mechanism of action:
- Alkylation of DNA (mainly N7 of guanine).
- Misleading in DNA replication-----> Cell Death.
- Alkylation in G1 & S phase.
- Cell death in G2 phase.
- Related drugs to alkylating agents: Procarbazine, Cisplatin & Dacarbazine
b) Antimetabolites:
1. Methotrexate: Folic acid antagonists.
- Binds to dihydrofolate reductase------> No folic acid synthesis.
- Lack of folic acid-------> No synthesis of adenine, guanine, thiamine & cytosil.
- Thiopurines: 6-mercaptopurines & 6- Thioguanine
- Cladibrine
- Fludarabines
- 5-flurouracil
- Cytarabine
1. Vinca alkaoids: Vincristine & Vinblastin (Tubule synthesis inhibitor).
2. Epidophyllotoxins: Inhibits Topoisomerase-II-------> DNA breakage.
3. Campothecin: Inhibits Topoisomerase-II.
4. Taxanes: Acts as spindle poison (mitotic).
d) Antiestrogen: Tamoxifen (Breast cancer).
e) Miscellaneous drugs:
![]() |
Miscellaneous anticancer agents |
This is an initiative to help our pharma community through spreading the knowledge. We are here committed to provide you high quality study material free of cost. If you also want to be the part of this initiative just like and share our facebook page so that more and more people can be benefited. Here is the link of our FB community: GPATCRACKERS
No comments:
Post a Comment